标签归档 西安耍耍

Pentium pony is about to attract brand-new models, so it’s really comfortable to have large space.

Space and vehicle comfort are closely related, and this car is brought to you today. Let’s take a look at it together.

First look at the appearance of the Pentium pony. The front of the Pentium pony looks very simple and generous, which makes people unforgettable. Coupled with tough headlights, it is very eye-catching. The car is equipped with etc. Come to the side of the car, the car body size is 3000MM*1510MM*1630MM, the car uses dignified lines, the car side looks very calm, with large-sized thick-walled tires, the shape is quite dignified. Looking back, the tail line of Pentium pony is fashionable, the taillights are very domineering and the shape is relatively simple.

In terms of interior, the interior modeling has taken a solid route and the visual effect is quite unique. The car looks very good outside the steering wheel, made of plastic, and feels good. Take a look at the central control. The design of the center console is reasonable, which makes the interior design quite layered, which is in line with the temperament of the car. Let’s take a look at the dashboard and seats again. The dashboard of this car presents a flamboyant design style, which is very eye-catching. The car uses a fabric seat, which is wrapped in place and has good support and comfort.

Pentium pony matching gearbox, 30KW, 90N.m, good power performance.

The car is equipped with Bluetooth /WIFI connection, sun visor mirror, USB interface, uphill assist, rear reversing radar and other configurations, which is quite rich in functions, which is undoubtedly very friendly to drivers.

After reading the above description, Xiaobian will make a summary. I wonder if you are excited about this car introduced today?

Notice of Beijing Municipal Bureau of Economy and Information Technology on Organizing the Publication of the Second Batch of Foundation Construction Projects for High-tech Industries in 2023

  In order to implement the decision-making arrangements of the municipal party committee and the municipal government on upgrading the modernization level of the industrial chain supply chain, and accelerate the construction of an international science and technology innovation center, according to the deployment of the "Development Plan for High-tech Industries in Beijing during the Tenth Five-Year Plan", based on enhancing the independent and controllable capabilities of the industrial chain and supply chain, focusing on the weak links of the industry, and carrying out the engineering research on key basic technologies and products, the second batch of high-tech industry foundation projects will be organized and unveiled in 2023.

  First, the research direction and support standards

  (A) the direction of tackling key problems

  1. The field of hydrogen energy

  (1) Direction of combined valve of 1)70MPa automobile hydrogen bottle

  2. Field of medical robots

  (1) High real-time tracking and intelligent navigation device for surgical robot.

  (2) Robot intelligent mobile platform

  (3) fracture reduction operation planning and control system

  3. The field of cell and gene therapy drugs

  (1)GMP-level transfection reagent

  (2) Cell cryopreservation solution

  (3) Cell reprogramming reagent

  (4) Cell cryopreservation bag

  (5) Large magnetic frame

  (6) Cell washing, concentration and liquid exchange equipment with ultra-Qualcomm capacity.

  (7) Gene Transduction Equipment

  4. Cloud native domain

  (1)OpenNJet HTTP3 state secret SSL suite module 

  (2)OpenNJet HTTP3 proxy module

  (3)OpenNJet MQTT protocol proxy module

  (4)OpenNJet WASM module

  (5)OpenNJet HTTP3 proxy enhancement module.

  (6)OpenNJet dynamic protocol plug-in module

  5. Database field (distributed relational type)

  (1) Research and development of key algorithms and module technologies for heterogeneous database migration.

  (2) Supporting standards

  For the project units registered in our city, support shall be given according to 30% of the investment for tackling key problems approved by the project, and the amount of support in a single direction shall not exceed 30 million yuan, and the funds shall be allocated annually.

  Second, the reporting requirements and instructions

  (a) reporting conditions and requirements

  1 to encourage enterprises and consortia with the ability to tackle key problems nationwide to expose the list. The party receiving the list should be in good operation and financial condition, and have no serious record of dishonesty in the past three years.

  2. The construction site of the project is in this city, which meets the requirements of this city’s industrial policy and has complete procedures. The research period should not exceed 3 years, and the start time should be later than January 1, 2023.

  3 to declare the project should not be supported by other municipal financial funds.

  4. The applicant shall submit the application materials as required. The applicant voluntarily fills in relevant materials, promises relevant matters, and is responsible for the authenticity and accuracy of the materials provided.

  (2) Time and process of declaration

  1. Detailed indicators and parameters of the research direction can be obtained by consulting the corresponding business offices in each direction (see Annex 2 for details).

  2. Eligible reporting units, please submit the materials (three sets of paper version and one set of electronic version) to the corresponding business offices in all directions as required (see the annex for details) before October 20, 2023. Paper version materials shall be made in accordance with A4 paper binding, and the cover and riding seam shall be stamped with the official seal of the project reporting unit.

  (3) Other matters

  1. The project unit shall carry out project management in accordance with the Measures of Beijing Municipality for the Management of Development Funds for High-tech Industries, and accept the follow-up inspection, acceptance review and performance supervision by the relevant departments of the urban area, such as the letter, finance and so on. In case of concealment, concealment, fraud or violation of commitments, Beijing Economic and Information Technology Bureau has the right to pursue relevant legal responsibilities and recover funds. At the same time, it will incorporate the untrustworthy information of the project unit into the Beijing public credit information service platform and implement credit punishment according to laws and regulations.

  2. Contact person for policy consultation:

  Planning Department: Zong Zhigang, 55578586; Zou Genhong, 55578179.

  Technical support: customer service staff of Beijing Tongqi Service APP, 82176966; Beijing high-tech industrial development fund system operation and maintenance personnel, 55578555.

National Health Commission: Strengthen the coordinated development of medical insurance and medicine

At the press conference held by the National Health and Wellness Committee on February 28th on the progress and effectiveness of health and wellness, Mi Feng, spokesperson of the Committee and deputy director of the Propaganda Department, introduced that the main health indicators of Chinese residents are currently in the forefront of middle-and high-income countries.

Continuously meet the health service needs of the people.

Zhuang Ning, deputy director of the Department of Physical Reform of the National Health and Wellness Commission, said that in recent years, the National Health and Wellness Commission has actively played a leading and coordinating role in medical reform and strengthened the coordinated development of medical care, medical insurance and medicine with relevant departments.

Zhuang Ning introduced that in terms of medical care, through the layout and construction of national medical centers, national regional medical centers, and provincial regional medical centers, we will strengthen relevant clinical key specialties and solve the problem of people seeking medical treatment across regions. According to statistics, in the first four batches of 76 national regional medical centers, more than 460 specialties have been built and more than 6,200 new medical technologies have been developed, and the average number of patients transferred to hospitals has dropped by about 30% compared with that before construction. The rate of common and frequently-occurring diseases in the county is over 90%.

Public hospitals are the main body of China’s medical service system. According to Jiao Yahui, director of the Department of Medical Administration of the National Health and Wellness Commission, there are 2,817 tertiary public hospitals and 5,384 secondary public hospitals participating in the performance appraisal of public hospitals nationwide. According to the data of the past five years, the development mode, operation mode and resource allocation of tertiary public hospitals in China are more reasonable. The two indexes reflecting the technical difficulty of medical services, namely, the case combination index and the proportion of discharged patients in Grade IV surgery, have increased by 10% and 23.5% respectively, and the application level of electronic medical records in 83% tertiary public hospitals has reached Grade IV or above. The number and proportion of doctors in short supply such as anesthesiology, pediatrics, and severe diseases in tertiary public hospitals across the country have increased, constantly meeting the needs of people’s health services.

Zhuang Ning said that in terms of medical insurance, China has further improved the universal medical insurance system, raised the per capita financial subsidy standard for residents’ medical insurance to 640 yuan, and continuously improved the level of general outpatient medical insurance for employees. In medicine, we will further expand the breadth and depth of centralized procurement of pharmaceutical consumables and further reduce the inflated price. Revise and improve the medical insurance drug list, improve the basic drug system, speed up the registration and listing of urgently needed drugs, children’s drugs and innovative medical devices, and strive to meet the people’s drug demand.

Continuously improve the ability of disease prevention and control

In recent years, China has continuously improved the multi-sectoral cooperation mechanism to enhance the ability of disease prevention and control. Qin Xingqiang, deputy director of the Comprehensive Department of the National Bureau of Disease Control and Prevention, said that the laws, regulations and policy systems related to the emergency response of infectious diseases in China have been continuously improved, and the emergency management system and mechanism have been continuously optimized, basically forming an emergency plan for public health emergencies, covering multiple diseases and covering national, provincial, municipal and county levels. Relying on the national and provincial centers for disease control and prevention, 20 national teams for the prevention and control of sudden acute infectious diseases have been set up, covering 17 provinces.

According to reports, since the "14 th Five-Year Plan", the central budget has allocated a total of 13.1 billion yuan to support the construction of disease control systems at the national, provincial, municipal and county levels. In 2023, the central government allocated 17.687 billion yuan for disease control projects through transfer payment for the prevention and control of major infectious diseases and endemic diseases.

Qin Xingqiang said that at present, the average reporting time of China’s infectious disease network direct reporting system has been shortened from five days to four hours now. At the national level, a technical system for rapid identification of 300 pathogens within 72 hours has been established, and 100% of provincial and 90% of municipal CDC have the ability to detect nucleic acids and isolate viruses. In the prevention and control of major infectious diseases, the rapid rise of AIDS epidemic in key areas has been effectively curbed; The mortality rate of tuberculosis remains at a low level; All endemic counties of schistosomiasis have reached the state of transmission interruption; Measles, Japanese encephalitis and other vaccines can prevent the incidence of infectious diseases from falling to the lowest level in history.

Construction of 321 high-level key disciplines of traditional Chinese medicine

In order to promote the development of China’s traditional Chinese medicine service system, Ouyang Bo, deputy director of the Comprehensive Department of the State Administration of Traditional Chinese Medicine, introduced that the State Administration of Traditional Chinese Medicine, the National Health and Wellness Commission and the National Development and Reform Commission took the lead in establishing an inter-departmental working mechanism with relevant departments, and the central government invested nearly 13 billion yuan to promote key tasks and major engineering projects to basically achieve "double half".

Ouyang Bo said that China’s traditional Chinese medicine inheritance and innovation has been steadily promoted-46 national traditional Chinese medicine inheritance and innovation centers have been built, and 50 superior diseases treated by traditional Chinese medicine, 52 integrated Chinese and Western medicine diagnosis and treatment programs, 100 appropriate technologies and 100 Chinese medicine varieties with unique curative effects have been selected and released. The official publication of the first batch of 74 books in the "Chinese Medical Collection" marks a major stage achievement in the compilation of ancient Chinese medicine books.

At the same time, the team of talents with Chinese medicine characteristics has been growing, training 50 Qihuang scholars, 500 national outstanding clinical talents of Chinese medicine, 100 young Qihuang scholars, 35 innovative teams of Chinese medicine, and building 321 high-level key disciplines of Chinese medicine.

According to preliminary estimates, in 2023, the total number of medical treatment in Chinese medical and health institutions was 1.28 billion, and the number of discharged patients was 41.486 million. Chinese medicine played an active role in serving people’s health.

Building a high-quality and efficient Chinese medicine service system is one of the main tasks of the development plan of Chinese medicine in the 14 th Five-Year Plan. In this regard, Ouyang Bo said that the State Administration of Traditional Chinese Medicine aims to achieve high-quality Chinese medicine services for everyone nearby, promote 14 Chinese medicine hospitals to be included in the founding unit of the National Medical Center, lay out and build 27 national regional medical centers for Chinese medicine, and continue to promote the construction of 62 "flagship" hospitals and 138 key hospitals with Chinese medicine characteristics. At the same time, optimize the supply of Chinese medicine services, select about 1,000 national traditional Chinese medicine specialties and 500 "flagship" departments for the coordination of Chinese and Western medicine, determine 31 units for the construction of Chinese medicine rehabilitation centers, strengthen the construction of pediatrics and geriatrics departments in Chinese medicine hospitals, and promote the construction of outpatient clinics for Chinese medicine specialties; Taking the construction of county-level Chinese medicine hospitals as the leader, we will build a solid grassroots network, promote tertiary hospitals to help 699 county-level Chinese medicine hospitals, and achieve full coverage of grassroots Chinese medicine museums in 23 provinces, so as to facilitate the masses to take a good look at Chinese medicine at their doorsteps.(Reporter Jin Zhenya)

More than 8 models of Tiggo were exposed to brake failure, and the problem pointed to brake by wire!

If you are the owner and prospective owner of Tiggo 8 PRO or Tiggo 8 PLUS, please note that there is something wrong with Chery’s brake-by-wire technology.

Recently, Master Jiao learned from relevant channels that Chery’s brake-by-wire technology has brought troubles to many car owners. The specific performance is as follows: 1. There will be a buzzer when braking; 2. The brake pedal becomes hard; 3. Brake failure; 4. Brake jitter. At present, it is understood that some car owners have formed rights protection groups and shared fault cases in the groups.

Please step on the brakes when the vehicle starts, but the owner has been stepping on the brakes.

The corner master found that a car owner was driving at a low speed of 30 kilometers per hour, and suddenly the brake pedal rebounded, and then a fault code appeared in the dashboard. At this time, the brake pedal felt hard and the hard-vegetable pedal vehicle appeared jitter.

At present, the official has not responded to this problem, and the owner has locked the root of the problem in the brake-by-wire technology. Because some owners of Tiggo 8 PRO and Tiggo 8 PLUS do not have such problems, the problem owners are mainly concentrated in the vast version of Tiggo 8 PRO and Tiggo 8 PLUS pride+,so what is Chery’s brake-by-wire technology?

In March 2022, Chery Automobile announced a major innovation when it launched the Tiggo 8 PLUS version. The braking system of the car was upgraded and the integrated brake-by-wire system of Bethel WCBS was adopted. The core technology of this system is to integrate the vacuum booster pump, master cylinder, electronic vacuum pump, EPB and ESC. The following figure shows the comparison between the integrated brake-by-wire system module and the traditional vacuum booster pump. Its main purpose is to reduce costs and enhance the competitiveness of products. In addition to cost reduction, the official said that this system can also coordinate energy recovery system and high dynamic pressurization capacity. In other words, most of Chery’s new energy vehicles will adopt the brake-by-wire system in the future.

Integrated brake-by-wire system

Traditional vacuum booster pump

However, at present, it is obvious that the technology is not yet mature, and some car owners equipped with brake-by-wire technology have become "mice". Master Jiao then went to the domestic third-party vehicle quality complaint platform to investigate and found that there have been centralized complaints about the models equipped with brake-by-wire technology in the Tiggo 8 PRO plate, and the most complained car in the Tiggo 8 PLUS plate is Haoqing+,which is also equipped with brake-by-wire technology.

Up to now, Chery officials have not responded to the vehicles with problems in the by-wire control technology. Judging from the problem of concentrated outbreak, Master Jiao’s personal guess may be that there is a problem with a batch of vehicles equipped with wire control technology. The failure of the brake system is a major personal safety hazard, and the manufacturer must attach great importance to it, and it is necessary to complete the upgrade, optimization and even recall of the problem model in a short time.

A few days ago, Chery Automobile just released the sales data in July 2022, and the group’s sales volume was 131,533, a year-on-year increase of 57.7%. This figure successfully surpassed 122,633 vehicles of Geely Automobile and 101,920 vehicles of Great Wall Motor. In terms of splitting, Chery’s total sales volume was 131,533 vehicles, of which 50,614 vehicles were exported, up 90.1% year-on-year. The sales volume of new energy was 25,614 vehicles, a year-on-year increase of 253%. It can be seen that the sales of new energy have surged, and in addition, the export volume has reached a new high. This is the happy side.

However, the safety hazard brought by the brake-by-wire technology hangs over Chery like a time bomb. However, if it is detonated, it will surely face the collapse of product quality reputation, and all efforts will be wasted.

Interview | Chinese and foreign research is on the cover of nature: this protein allows robins to navigate geomagnetic.

Human eyes can see all kinds of colors in the visible light band, and ears can hear sounds in the frequency range of 20-20000 Hz, but we still don’t know whether we have the sense of sensing the earth’s magnetic field, which is a complete mystery.

The public calls it "the sixth sense", but scientists don’t like this statement. In the past few decades, they have been trying to pry open the tip of the iceberg of the mystery and find a breakthrough in birds. How do they realize the induction of geomagnetic field and use it? European Robin is an excellent research object. This nocturnal migratory bird has been proved to have the ability of geomagnetic navigation before, and they can use the geomagnetic field as weak as 0.5 gauss for long-distance orientation to complete the seasonal migration year after year.

But what is the mechanism behind it? For this question, it needs a highly interdisciplinary cooperation to answer one or two. At 23: 00 on June 23rd, Beijing time, the top academic journal Nature published a heavy research titled "Magnetic sensitivity of cryptochrome 4 from a migratory songbird" on the cover form, which was jointly completed by scientists from Germany’s Oldenburg University, England’s Oxford University, China Academy of Sciences’ Hefei Institute of Material Science, Purdue University, University of Texas Southwest Medical Center and Germany’s Freiburg University. Studies have proved that cryptochrome protein (Cry4) in birds’ retina is very sensitive to magnetic field, and it may be the long-sought magnetic sensor.

There are 6 corresponding authors in this study, one of whom is Xie Can, a researcher from the High Magnetic Field Science Center of Hefei Institute of Material Science, China Academy of Sciences, and the High Magnetic Field Science Center is the common communication unit. Together with the team of the University of Oldenburg, Xie Can’s laboratory successfully prepared and obtained the Cry protein of European robin, a nocturnal migratory bird, for the first time in the laboratory, which laid the foundation for the success of the whole study.

In an interview with The Paper (www.thepaper.cn), Xie Can said that this multi-party cooperation, which started in 2016, is only the first stage of research on biomagnetic induction in various laboratories. "This article is also the first stage of our long-term cooperation." There is still a lot of work to be explored by its laboratories and partners in the future.

Xie Can graduated from the Institute of Genetics and Developmental Biology, Chinese Academy of Sciences in 2001 with a doctorate in science. In August of the same year, he went to the United States to study molecular biophysics and structural biology in Timothy Springer laboratory of Harvard Medical School. From 2009 to 2019, he was a professor at Peking University College of Life Sciences. In November 2019, he was invited to join and transferred to the High Magnetic Field Science Center of China Academy of Sciences as a researcher. In December, 2020, we jointly established the International Magnetic Biology Frontier Research Center (IMF RC).

It is worth mentioning that in 2016, Xie Can Laboratory published its original breakthrough in the field of animal magnetic induction and biological navigation in the international academic journal Nature Materials, and discovered the magnetic receptor gene for animals’ perception of magnetic field for the first time in the world. The magnetic induction protein (MagR) encoded by this gene has intrinsic magnetism and can form a complex with Cry protein, so as to recognize the external magnetic field and respond. Based on this, Xie can put forward the hypothesis of "biological compass" for animals to feel magnetism. This work was rated as "Top Ten Progress in Life Sciences in China in 2015".

Professor Peter Hore from the Laboratory of Physical and Theoretical Chemistry of the Department of Chemistry of Oxford University is also the corresponding author of this latest study. Hore is one of the main schools of biological magnetic induction hypothesis, that is, the main contributor to the chemical radical-pair model that relies on cryptochrome. In an email to The Paper (www.thepaper.cn), he wrote, "If we can prove that Cry4 is a magnetic receptor molecule, we will also prove a fundamental quantum mechanism, which enables animals to perceive extremely weak environmental stimuli, and the intensity of this stimulus is one million times weaker than previously thought".

Referring to the above hypothesis of chemical free radicals, the time should be set back to 1978. At that time, German chemist Klaus Schulten and others proposed a preliminary model to introduce quantum entanglement into this research field, arguing that the magnetic induction mechanism of birds involves the entangled state of free radical pairs. Schulten’s team finally published the research results in 2000, pointing out that cryptochrome is probably the key molecule in the process of bird magnetic navigation, and boldly speculated on the magnetic induction process.

After nearly 20 years’ development, the outline of this hypothesis has become increasingly clear: firstly, the photosensitive pigment auxiliary group FAD in cryptochrome absorbs the energy of a blue photon, which causes the electronic transition of FAD group, leaving an empty orbit; Then the electrons are taken from the four adjacent tryptophan in turn, which is "electron transfer". At this time, the separated electrons have both spin singlet and triplet states due to quantum entanglement. Finally, the delicate balance between the two states can be determined by the direction of geomagnetic field, and this information can be transmitted to the brain in some way, so that organisms can respond to geomagnetic information.

The research team systematically and completely summarized the basic principles and supporting evidence of the free radical pair hypothesis from physics, chemistry and biology.

Compared with the previous theoretical research, this multi-party cooperative research takes the cryptochrome 4 protein of European robin as the main research object, carries out a series of high-precision spectroscopic tests, and carries out computational biology simulation, thus realizing the mutual verification of theory and experiment. This is the first comprehensive explanation of the photochemical magnetic sensitivity of free radicals in cryptochrome protein of nocturnal migratory birds, which confirms and perfects the magnetic induction mechanism of free radicals and provides an important basis for further explaining the geomagnetic orientation behavior of migratory birds.

Functional Cry4 protein from migratory birds

As early as 2000, scientists proposed that the photosensitive protein cryptochrome (Cry) was a possible magnetic induction protein through theoretical calculation. Theoretically, under the blue light condition, the information of external magnetic field can be transformed into the change of quantum yield caused by photoinduced free radicals in cryptochrome protein, which can be perceived by cells.

Why is cryptochrome protein considered by scientists as an animal magnetic induction molecule? The first author of this paper, Xu Jingjing from the University of Oldenburg, explained to the reporter of The Paper (www.thepaper.cn) that cryptochrome protein can bind to flavin adenine dinucleotide (FAD), also known as active vitamin B2. When FAD is excited by blue light, it will undergo a reduction reaction, which can seize the electrons of tryptophan (Trp) nearby in turn, thus forming a magnetically sensitive free radical pair [FAD-TrpH+].

"It can be said that FAD is the’ heart’ of this magnetic sensitive molecule, and only cryptochrome protein combined with the cofactor FAD has the prerequisite of magnetic sensitivity." Xu Jingjing is now a doctoral student in Henrik Mouritsen’s laboratory of the University of Oldenburg. Before studying in Germany, Xu Jingjing completed his master’s degree in the Institute of Electrician, Chinese Academy of Sciences, and received biochemical training in Professor Xie Can’s laboratory. .

It is worth mentioning that one of the reasons why the hypothesis of free radical magnetic induction has not been proved by experiments in birds since it was put forward in 1978 is that the recombinant expression of avian cryptochrome protein often loses its own function because of protein’s misfolding, which means the loss of the key auxiliary group FAD for cryptochrome.

"The biggest regret of free radicals to the hypothesis is that scientists have never been able to obtain experimental evidence of the magnetic sensitivity of cryptochrome protein in migratory birds. In the early attempts, some experiments were done in the laboratory with cryptochrome protein of plants or non-migratory animals, but as the most typical migratory animals, migratory birds have never been really studied because of the difficulty in purifying cryptochrome protein of birds. " Xie can added.

In this study, scientists finally obtained the functional cryptochrome protein of migratory birds that combined with FAD. Under the guidance of Xie Can and Mouritsen, Xu Jingjing expressed and purified Cry4 protein of nocturnal migratory birds with biological activity by using the Cold-Shock protein expression system customized and optimized in the laboratory. The protein sample showed a beautiful and transparent yellow-green color due to the presence of FAD chromophore, and mass spectrometry analysis showed that the FAD binding rate of the protein was as high as 97%. It laid the foundation for the success of the whole study.

The acquisition of Cry4 protein of European robin is actually quite tortuous. Xie Can told the The Paper reporter that as early as the beginning of the cooperation, that is, in April 2016, the original plan was that Xie Can’s laboratory would prepare the protein in China, and then send it to the foreign cooperation team by air transportation for the next test.

In the previous research on MagR, Xie Can has successfully expressed and purified the MagR and Cry proteins of homing pigeons (birds that can homing directionally but not migrate seasonally) and their complexes.

But the international transportation scheme is not feasible. Xie Can clearly remembers that on June 9, 2016, his laboratory sent samples to Oxford University for the first time, but it was difficult. "Long-distance international transportation of protein samples requires that the protein be frozen first, and then thawed after reaching the destination laboratory. At that time, we found a problem. Whether it is Cry protein, MagR protein discovered by ourselves, or a complex of the two, all these proteins related to magnetic induction are very unstable and extremely sensitive to temperature. In the process of freezing and thawing, the activity of protein is greatly reduced or even disappeared. " For Cry4 protein in this study, after long-distance transportation and freezing and thawing, the key FAD auxiliary group was dissociated from Cry4 protein, and Cry4 protein also lost its activity.

Under the circumstances at that time, how to "preserve" Cry protein was an urgent problem to be solved. Just then, Xu Jingjing was applying for a visiting scholar in Mouritsen Laboratory. In November 2016, Mouritsen put forward a proposal to let Xu Jingjing go directly to Xie Can’s laboratory to learn a whole set of protein expression and purification techniques. Under the framework of cooperation, Xie can is very open-minded. "This is also a good thing for us, because the articles we publish ourselves also hope that others can repeat them." After more than two months of intensive "crash course", Xu Jingjing entered the Mouritsen laboratory.

"It took about seven or eight months for Xu Jingjing to set up the whole system from scratch in Mouritsen laboratory, and the expression and purification of Cry4 protein were perfectly repeated, and it also had good activity." After the key cornerstone work was completed, Hore and Mouritsen could not hide their excitement. They expressed their excitement in the email sent to Xie Can, that is, at that moment, the three parties formally established a long-term cooperation. "The three of us are completely different backgrounds. Hore is a physicist, so he mainly does physical chemistry. Mouritsen does animal behavior and neurobiology. I do protein research, so the three of us have their own strengths, which can complement each other." Xie Can described this tripartite cooperation in this way.

 In the following two years, Xu Jingjing usually finished protein preparation in the morning, then took a flight from Germany to Britain, arrived at Oxford University in the afternoon and went straight to the laboratory to test the properties of the protein, that is, the magnetic sensitivity of free radicals to photochemical reactions. Xie can once "experienced half a trip" when she visited Oxford University. "I can realize that she basically shuttled between laboratories in two countries for more than two years, and this is how the experiment was done." Xie can said.

For the first time, the hypothesis of free radical pair was verified by the experiment of cryptochrome protein of migratory birds

In the course of this research, in view of the complexity of the experimental content and the extremely complicated tests involved, more laboratories joined in. It is mentioned in the paper that in order to study the influence of magnetic field on the photochemistry of cryptochrome, the research team has developed and continuously improved a variety of spectral techniques.

The research team of Oxford University has developed a series of spectroscopic techniques specially used to study the photochemical magnetic field effect of cryptochrome, including transient absorption spectroscopy and Cavity ring-down spectroscopy. Broadband cavity-enhanced absorption spectroscopy and electron paramagnetic resonance. Hore described it this way, "These devices were developed by the joint efforts of generations of talented postdoctoral and graduate students in the laboratory for many years."

Xu Jingjing said, simply put, the researchers put the protein sample in a magnetic field and irradiated it with 450nm blue light to detect the light absorption changes of the protein transient free radical pair under different magnetic field conditions and different time resolutions.

The experimental results showed that the free radicals in cryptochrome protein changed the yield after the magnetic field was applied, that is, the magnetic field effect, and the magnetic field effect of cryptochrome protein of European robin was 10 to 20 times stronger than that of non-migratory birds (chickens and pigeons).

The research team also clarified the mechanism of this magnetic sensitivity, that is, the electron transfer reaction triggered by blue light absorption. Protein molecule is composed of a series of amino acids: Cry4 has 527 amino acids, of which 4 tryptophan is very important for magnetic sensitivity. Under the excitation of blue light, electrons jump between FAD and these four tryptophan, resulting in so-called magnetically induced free radical pairs. Peter Hore of Oxford University and Ilia Solov’yov, a physicist in oldenburg, have calculated quantum mechanics to support this view.

In order to verify this, researchers at the University of Oldenburg further prepared tryptophan mutant protein of cryptochrome, that is, four tryptophan (WA, WB, WC and WD) in the electron transfer chain were replaced by phenylalanine (F) in turn, which had no redox activity and could not provide electrons to FAD, thus cutting off the electron transfer chain.

In each mutant protein, the electron transfer chain is 3, 2 and 1 tryptophan in turn. The transient absorption spectrum test results show that the free radical pair life of mutant protein is shortened from microsecond to nanosecond and picosecond. Electron paramagnetic resonance (EPR) test showed that the free radicals of wild-type protein [FAD+TRPDH+] were 2.2nm apart, and after the fourth tryptophan was mutated, the free radical pair [FAD+TRPCH+] was 1.8nm apart.

The paper points out that the experimental results are consistent with the theoretical simulation. In wild-type cryptochrome protein, electrons are transferred among four tryptophan in turn, and these four steps make the electrons that are not equipped at the end be the farthest apart, thus forming a long-lived free radical pair, and the ultra-fine effect of the latter’s spin coherence is the point of magnetic field action.

Xu Jingjing mentioned that, surprisingly, when the fourth tryptophan at the farthest end was mutated, the magnetic field effect of protein was stronger than that of wild-type protein, and it was stronger than that of cryptochrome in Arabidopsis thaliana, which is also an electron transfer chain of tryptophan.

The researchers asked, why did nature evolve a fourth tryptophan for avian cryptochrome protein, if its function was only to reduce the sensitivity of magnetic field? Further research shows that the decay kinetics of wild-type protein (ErCry4) and mutant (ErCry4 WDF) are similar in milliseconds, and the magnetic field dichotomy (B1/2) is similar. This means that the origin of their magnetic sensitivity is the same, both of them come from the third tryptophan, and the fourth tryptophan may not participate in the animal magnetic induction process.

So what role does this fourth tryptophan-mediated electron transfer play? Based on the above experimental results, Ilia Solov’yov and Hore put forward the mechanism of free pair dynamic equilibrium through spin dynamic simulation, that is, electrons may jump back and forth between the third and fourth tryptophan, and the resulting two free radical pairs [FAD-TRPCH+] and [FAD+TRPDH+] are in rapid dynamic equilibrium and play different roles respectively.

The two roles are: the free radical pair formed by flavin-third tryptophan is mainly responsible for magnetic field perception, and the free radical pair formed by flavin-fourth tryptophan is mainly responsible for biochemical signal transmission in vivo. "This mechanism has not been found in cryptochrome proteins of any species before." Xie can said.

The research team predicts that there may be other proteins interacting with cryptochrome proteins in the body, such as MagR or other unidentified signal molecules reported by Xie Can, to realize cascade amplification of signals or directional arrangement of cryptochrome proteins, and further enhance the magnetic sensitivity and direction recognition in organisms. "Of course, these speculations need more experiments in the future to confirm."

They speculated that, perhaps, it was through this ingenious mechanism that nature wonderfully optimized the free radical photochemical reaction of cryptochrome protein and realized the dual functions of magnetic field sensing and signal transmission, thus enabling migratory birds to find their way in their journey across the hemisphere.

Xie Can concluded to the The Paper reporter that the main breakthroughs of this study are as follows: first, the hypothesis of free radical pair is verified experimentally with cryptochrome protein of migratory birds; Secondly, it is found that cryptochrome protein 4 of migratory birds is more sensitive to magnetic field than that of non-migratory birds; Thirdly, it is found for the first time that the four conserved tryptophan in the hypothesis have two different functions: magnetic induction and signal transmission.

Moving forward in controversy, in vivo verification is not easy.

It is worth noting that there are still many controversies in the field of animal magnetic induction research.

Xie Can said that on the whole, the magnetic induction hypothesis that has attracted much attention so far mainly includes electromagnetic induction model, magnetite particle model, chemical free radical pair model dependent on cryptochrome and biological compass model. These hypotheses are supported by certain experimental evidence, but there are also some limitations or deficiencies.

Xie Can called the study of animal magnetic induction a "very non-biological" study. By analogy with the conventional research ideas of sensory biology, scientists have first known for sure the existence of a certain sensory system and what kind of sensory organ it is, and on this basis, they have identified the receptor cells, neural pathways and brain regions related to the sensory system.

But the study of magnetic induction is quite different. In this field, biologists often find and ask questions, but physicists put forward imaginative hypotheses, and then chemists will also participate in a large number of verification experiments. Previously, the discovery of MagR and the hypothesis of biological compass in Xie Can’s laboratory generally followed this thinking paradigm.

Although this latest research has made many important breakthroughs, Hore stressed that this is not conclusive evidence that cryptochrome is a magnetic sensor. Because "this study is an in vitro experiment with purified protein, and the magnetic field used in the experiment is much higher than the geomagnetic field." Henrik Mouritsen said, "We need to prove the sensitivity of this protein to geomagnetic field in birds’ eyes, but the current technical bottleneck does not allow us to do this."

The research team speculated that cryptochrome protein may show higher sensitivity to magnetic field in vivo environment. For example, in retinal cells, protein may be arranged in a fixed orientation, thus enhancing their sensitivity to the direction of magnetic field. In addition, they may interact with other proteins, such as the previously reported magnetic receptor MagR, and even other unidentified protein, so as to achieve the effect of signal cascade amplification. Scientists are also looking for these unknown "mutual partners".

Regarding the future research plan of this project, Xu Jingjing pointed out that finding the interaction protein of cryptochrome and conducting in vivo experiments are two major challenges.

In fact, up to now, even though the evidence of free radicals is the most comprehensive, many hypotheses of animal magnetic induction mechanism need to be continuously developed, improved and screened. "There are many schools in the field of magnetic induction, and the publication of every research result needs to be widely questioned and challenged by reviewers in the review process, and these reviewers often come from different academic schools with different academic viewpoints, and they are often your competitors. Only by persuading your competitors will it be possible to finally publish it through review. " The review of this paper for nearly two years also highlights the twists and turns of the process.

Xie can prefers to call this kind of controversy in the scientific community academic debate. "The extensive academic controversy and debate itself shows that the problem you are studying is very important, which is obvious." Secondly, Xie Can believes that with the academic controversy and debate, it often brings about the rapid development of the whole field, "because more and more rigorous experiments will be designed to verify their respective views. Whether it is proof or falsification, we are getting closer and closer to the truth of science. "

Xie Can believes that the field of animal magnetic induction is full of controversy, "because no hypothesis or model has been recognized by everyone so far, and each school has its own supporters."

Strong cooperation like this one may bring about accelerated progress. "This is a highly interdisciplinary field. If you want to do some interesting topics in the field of animal magnetic induction and biological navigation, it is often impossible to rely on a laboratory to complete it." Xie can said.

Xu Jingjing also mentioned that "solving a scientific problem requires the joint efforts of many disciplines. In our team, experts in various disciplines have world-class technology, which is very important for our research." She said that in the process of project promotion, researchers kept communicating and understanding the knowledge of different disciplines to achieve common scientific goals.

Flora, the health guard in the intestine

There are more than 10 trillion huge microbial groups in human skin and intestines, and their number is more than 10 times of the total number of human cells, which is considered as another set of genomes besides human cells. Under normal circumstances, the vast majority of bacteria in the gastrointestinal tract are beneficial to the human body, but due to various factors, the intestinal flora will also be unbalanced, and once it is unbalanced, it is easy to induce various chronic diseases.

The second organ of the human body

We collectively refer to the bacteria living in the intestine as intestinal flora. Their total weight in the human body is 2~3 kg, and there are more than 1,000 species. More than 50% of the feces we excrete every day are composed of these bacteria and their corpses. These small bacteria are symbiotic with our human body. They are rooted in the intestine for a long time to maintain our health, so we also call the intestinal flora "the second organ of the human body".

First of all, intestinal flora can shield and influence the immune system by itself, and prevent pathogenic bacteria from invading the human body. Intestinal flora adheres to the mucosal layer on the surface of the inner wall of the intestine, forming a barrier composed of bacteria. Intestinal flora inhibits the growth of pathogenic bacteria through the dominant symbiotic bacteria activities, and prevents pathogenic bacteria from entering the human body through this barrier. At the same time of passive defense, intestinal flora can stimulate the body to form more lymphatic organs in the intestine, and increase the level of immunoglobulin in plasma and intestinal mucosa, so that the immune system is in a moderately active state, so as to maintain an effective immune effect on invading pathogens.

In addition, intestinal flora has regulating and nutritional effects on the intestine. It has been reported that the existence of intestinal flora, especially the nutritional function of short-chain fatty acids produced by it, can make the growth of intestinal epithelial cells more active. In addition, intestinal flora can also regulate the differentiation of intestinal mucosal epithelial cells. This means that with normal intestinal flora, intestinal mucosa can be repaired more quickly.

Recent studies have shown that intestinal flora has an important relationship with human metabolic diseases. In addition, there are many other relationships between intestinal flora and health. Carotenoids produced by intestinal flora can reduce the risk of atherosclerosis and stroke to some extent. Normal intestinal flora can regulate the body’s response to allergens through the influence on lymphocytes, thus affecting the occurrence of allergic diseases. Even more surprising, there is evidence that the structural changes of intestinal flora can even affect the behavior patterns of the body.

Bacteria are also divided into good and bad

"Bacteria exceeded the standard" and "food was found to have bacteria" … People often talk about "bacteria" discoloration, but they don’t know that bacteria are also good or bad. Microbial communities are constantly influenced by many factors in the process of growth, including heredity, age, gender, diet and lifestyle. Everyone’s intestinal microbes have their own characteristics, but in healthy individuals, the relative abundance and distribution of bacterial species are very similar, and they all play a role in maintaining people’s overall health. There are "beneficial bacteria" that provide positive energy, "harmful bacteria" that love to make trouble, and some originally harmless bacteria that may take advantage of the situation and cause harm to the body. Such bacteria are called "opportunistic pathogens" or "conditional pathogens".

The normal flora of gastrointestinal tract can be divided into aerobic bacteria, facultative anaerobic bacteria and anaerobic bacteria. The most dominant is anaerobic bacteria, accounting for 99% of the total flora. The types and quantities of bacteria in the stomach, duodenum and jejunum are less, and the bacteria in the ileum begin to increase. In the colon, the types and quantities of bacteria increase more significantly, most of which are anaerobic bacteria, and Bifidobacterium, Bacteroides and Lactobacillus are absolutely dominant, while Clostridium and Staphylococcus, which are potentially pathogenic, account for only a few.

The imbalance of flora leads to many diseases.

If the intestinal flora is out of balance, health will go wrong. When beneficial bacteria can’t compete with harmful bacteria or conditional pathogens, they show bacterial infection, and symptoms of gastrointestinal diseases such as diarrhea, abdominal pain, vomiting and fever appear. For example, the endotoxin produced by the imbalance of intestinal flora will increase the burden of liver detoxification and cause liver damage. These toxins will also enter our brain, causing abnormal brain development, causing autism, depression, Alzheimer’s disease and other symptoms. In addition, the imbalance of intestinal flora will also lead to cardiovascular and cerebrovascular diseases such as atherosclerosis.

There are five main reasons for the imbalance of intestinal flora: 1. Long-term unbalanced diet. For example, eating too much meat or vegetables and eating unhealthy food for a long time; 2. Ingestion of food contaminated by bacteria. Reduce resistance, make conditional pathogens "worse", or ingest too many harmful bacteria, imbalance of intestinal flora, and diarrhea symptoms; 3. Age increases. With the increase of age, some beneficial bacteria decrease and harmful bacteria increase, and the body’s immunity weakens; 4. Use certain drugs. Excessive use of antibiotics leads to imbalance of intestinal flora and decreased immunity; 5. Gastrointestinal dysfunction. Organic causes lead to imbalance of intestinal flora and decreased immunity.

Diet regulation is safe and effective.

Now we have a safe, effective and scientific conditioning method, that is, taking microecological preparations. This preparation mainly includes three types, namely probiotics, prebiotics and synbiotics. Probiotics contain a certain number of live bacteria preparations; Prebiotics can promote the growth of intestinal probiotics; Synbiotics is a mixture of probiotics and prebiotics, which can not only supplement the probiotics in our body, but also promote the growth of probiotics.

Yogurt is a good choice to supplement probiotics. It contains plenty of protein, and also contains Lactobacillus bulgaricus and Streptococcus thermophilus, but these two kinds of bacteria can’t colonize in our intestines, and yogurt at room temperature contains no live bacteria.

In addition to yogurt, there are many lactic acid bacteria drinks on the market at present. This kind of drink has a very high sugar content, and its nutritional value is relatively low compared with yogurt. Moreover, most of these drinks are stored at room temperature, so it does not contain live bacteria.

There is also an active lactic acid bacteria beverage, which requires strict cold chain transportation and cold storage. However, for people with gastrointestinal discomfort, drinking cold drinks often stimulates the intestines, and there is no way to guarantee the probiotic activity contained in such drinks.

In addition, bad eating habits will destroy the balance of intestinal flora, for example, a high-fat diet will change the intestinal flora. Adjusting the dietary structure and developing good eating habits play an important role in maintaining the dynamic balance of intestinal flora.

Intestinal flora changes with age, and some studies show that the number of bifidobacteria in the intestine of the elderly is significantly reduced. Therefore, in the diseases related to intestinal flora imbalance in the elderly, proper application of microecological agents is conducive to the recovery of the health of the elderly.

Commonly used microecological agents include live bacterial agents such as Bifidobacterium, Lactobacillus and Enterococcus. Increasing the number of beneficial bacteria can not only regulate the balance of intestinal flora, but also enhance the immunity of the body. ▲ (This lecture was written by Cui Yuyan, a special correspondent of this newspaper)

Don’t deprive children of their childhood happiness again! The Ministry of Education stopped kindergarten "primary school"

  CCTV News:In recent years, for the sake of their own interests, individual kindergartens have violated the laws of children’s physical and mental development and cognitive characteristics, taught primary school content in advance, and strengthened knowledge and skills training. The tendency of "primary school" education is serious, which not only deprives children of their childhood happiness, but also dampens their interest in learning.

  Recently, the General Office of the Ministry of Education issued"Notice on Carrying out the Special Governance of Kindergarten" Primary School "(hereinafter referred to as the" Notice "),Clear governance tasks, governance steps, etc. Relevant departments are required to promote kindergartens to establish a scientific concept of protecting education, implement games as the basic activity, and resolutely correct the tendency of "primary school" through self-examination, comprehensive rectification and special supervision.

  Governance task

  It is forbidden to teach the content of primary school curriculum.

  The "Notice" requires that those who teach Chinese pinyin, literacy, calculation, English and other primary school curriculum contents in advance should be resolutely banned.

  For kindergartens to arrange children to complete homework and organize exams and tests related to primary school content, we must resolutely correct them.

  Social training institutions are also not allowed to teach primary school content in advance in the name of preschool and young convergence, and all localities should standardize it in combination with the governance of off-campus training institutions.

  In view of the fact that kindergartens can’t stick to games as their basic activities and break away from children’s life scenes, they organize and arrange one-day activities mainly by means of centralized classroom teaching; Or by mechanical recitation, memory, copying, calculation, etc., the "Notice" requires that it be resolutely corrected.

  It is necessary to guide kindergarten directors, teachers and parents to establish a scientific concept of child-rearing, adhere to the principle of children-oriented, respect children’s learning interests and needs, take games as the basic activities, flexibly use various forms such as group, group and individual activities, reasonably arrange and organize children’s daily life, and promote children’s independent games and learning inquiry through personal experience, direct perception and practical operation.

  Rectify the "primary school" educational environment

  The "Notice" requires that for those who fail to create various activity areas (corners) according to regulations, do not provide enough playing AIDS, game materials and books, and lack an educational environment that stimulates children’s interest in inquiry, strengthen their physique and play independently, they should adjust the setting of kindergarten activity areas, make rational use of indoor and outdoor environments, create open and diverse regional activity spaces, and equip them with necessary playing AIDS, game materials and picture books that meet the age characteristics of children; We should make full use of local life and natural resources, select, develop and design a number of game activities suitable for children, enrich game resources and meet the basic needs of children to carry out game activities.

  The "Notice" requires that those who do not have the qualifications of kindergarten teachers should be urged to participate in professional skills compensation training and obtain the qualification certificate of kindergarten teachers through examinations. If they still cannot obtain the qualifications of teachers, they should be adjusted within a time limit.

  For those who don’t meet the needs of scientific teaching, are used to "primary school" teaching, and are not good at organizing game activities according to the laws and characteristics of children’s physical and mental development, it is necessary to improve kindergarten teachers’ scientific teaching ability by carrying out standardized training on post adaptability.

  Primary schools adhere to zero starting point teaching.

  The "Notice" requires that those who fail to implement zero-starting teaching, reduce class hours and exceed the standard in accordance with the national curriculum standards in the initial grade of primary schools, and organize knowledge and ability tests of primary school content for children in enrollment, or take children’s participation in relevant competitions and certificates as the basis for enrollment, we must resolutely correct them, and investigate the responsibilities of principals and relevant teachers according to specific circumstances, and incorporate them into the record of standardized school running integrity.

  Governance steps

  Special treatment is divided into four stages.

  The first stage:Full deployment. Local education administrative departments at all levels should carefully formulate governance plans, clarify work requirements, and complete them before the end of August 2018.

  The second stage:Self-examination and arrangement. Kindergartens, primary schools and training institutions conduct self-examination as required, and the education administrative department organizes spot checks and arranging, which will be completed by the end of December 2018.

  The third stage:Comprehensive rectification. According to the situation of self-examination and arrangement, we should persist in making corrections while checking and timely rectification, and resolutely correct all kinds of wrong behaviors with the tendency of "primary school". The overall rectification work will be completed by the end of April 2019.

  The fourth stage:Special supervision. The State Council Education Steering Committee Office, Ministry of Education and provincial education supervision institutions and education administrative departments will carry out special inspections, which will be completed before the end of June 2019.

  Implement one-vote veto for annual inspection

  The "Notice" requires that kindergartens, primary schools and social training institutions with irregular teaching behavior and a tendency of "primary school" should be ordered to make rectification within a time limit. For those with frequent problems and strong social reactions, one-vote veto should be implemented in the annual inspection, and the main responsible person should be seriously investigated.

  Set up a special telephone and mailbox for reporting supervision.

  Education administrative departments at all levels should set up special telephone and mailbox for reporting and supervision, and consciously accept the supervision of parents and society. We should make full use of all kinds of media, increase publicity, widely publicize the scientific concept of parenting, and create a good environment for the healthy development of children’s body and mind.

  Sound sound

  In the face of the Ministry of Education’s efforts to manage the "primary school" of kindergartens, some netizens have expressed their views.

  — — Some netizens think that we should take measures to govern and give children a happy childhood. Early childhood education should pay more attention to the cultivation of behavior habits.

  — — For the "primary school" of kindergartens, parents expressed their helplessness.

   What do you think? Welcome to leave a message

  Source: CCTV News, Xinhua News Agency

Be listed as a definite carcinogen! This kind of bacteria is infected by more than half of people in our country.

Hp

Recently, the U.S. Department of Health and Human Services released the 15th edition of the carcinogen report, in which 8 carcinogens were added, and Helicobacter pylori was listed as a definite carcinogen for the first time.

In China, the average infection rate of Helicobacter pylori is nearly 60%. Is there a high probability of cancer after being infected with this bacterium? What are its transmission routes? How to prevent it? Earlier, the reporter from the General Station interviewed the experts in the Department of Gastroenterology of Beijing Friendship Hospital affiliated to Capital Medical University on related issues.

How common is Helicobacter pylori?

According to related reports, Helicobacter pylori infection is the most common chronic bacterial infection in human beings, accounting for more than 50% of natural bacterial infections in the world. Among them, the infection rate in developing countries exceeds that in developed countries. There are obvious differences in the probability of Helicobacter pylori infection in different regions of China, with an average infection rate of 59%, of which the average infection rate of children is 40%.

△ Helicobacter pylori (data map)

Infection with Helicobacter pylori has a high risk of cancer?

It is a misunderstanding that there is a high risk of cancer if Helicobacter pylori is positive.

According to the current research, most people who are positive for Helicobacter pylori have no great harm and symptoms, and only 10% to 20% of infected people will have digestive tract ulcers. Less than 1% of infected people develop gastric mucosa-associated lymphoid tissue lymphoma, which may be at risk of canceration.

Most people infected with Helicobacter pylori have no clinical symptoms and complications.

Experts say that most people infected with Helicobacter pylori have no clinical symptoms and complications, and they can detect whether they are infected with Helicobacter pylori by using the most commonly used non-invasive methods, including carbon-13 or carbon-14 breath test.

Can helicobacter pylori be eradicated? How to eradicate it?

According to experts from the Department of Gastroenterology, Beijing Friendship Hospital, Helicobacter pylori can be eradicated. But first of all, we should evaluate whether there are indications for radical cure before we do treatment. Young people with no special family history and asymptomatic infected people are not recommended for eradication treatment. At present, bismuth-containing quadruple therapy has become the first-line treatment scheme to eradicate Helicobacter pylori. Experts suggest that to eradicate Helicobacter pylori, you should take medicine regularly according to the doctor’s advice.

How to prevent infection with Helicobacter pylori?

Helicobacter pylori is mainly transmitted through mouth-to-mouth and feces-to-mouth routes. Daily behaviors such as gathering, eating water or food infected by Helicobacter pylori, not washing hands after contact between humans and animals, kissing, and "mouth-to-mouth" feeding children may all be infected with Helicobacter pylori.

△ Data Map (Source/vision china)

Stay away from Helicobacter pylori, you should develop these habits.

Disinfect tableware and divide meals.

Do not eat raw or too hot food. They will stimulate the gastric mucosa and reduce its resistance, thus creating conditions for the invasion of Helicobacter pylori.

Don’t "mouth to mouth" feed. Some old people like to feed their children with food, which is one of the most easily contagious ways.

Wash your hands and clean your mouth in time.

High-risk groups should have regular physical examinations. The high-risk population of Helicobacter pylori should have gastroscopy every 2~3 years, and adults under 50 years old should have gastroscopy every 3 years. Those over 50 years old should do it every two years.

Source: CCTV News

Original title: "It is listed as a clear carcinogen! More than half of people in China are infected with this bacterium.

Read the original text

Press Conference of "2022 Henan Internet Development Report"

Press conference video

  At 15: 30 on May 17th, 2023, the Information Office of the provincial government held a press conference of "2022 Henan Internet Development Report".

  Release content:Introduce and interpret the specific situation of "2022 Henan Internet Development Report" and the development of the Internet industry in Henan Province, and answer questions from reporters.

  Published by:

  Member of the Party Group and Deputy Director of Changjiang Provincial Communications Administration

  Zhao Huiqun Honorary Chairman of Provincial Internet Association

  Fan Peiquan, Member of the Party Committee and Deputy General Manager of Henan Mobile Company

  Chen Shigang Member of the Party Committee and Deputy General Manager of Henan Unicom Company

  Li Jirui, Senior Vice President of Henan Telecom Company

Press Conference of "2022 Henan Internet Development Report"

  Chang Yiyuan, Director of Press Release Office of Propaganda Department of Provincial Party Committee

  Ladies and gentlemen, friends from the media,

  Hello everyone! Welcome to the press conference held by the Information Office of Henan Provincial People’s Government.

  In order to comprehensively and objectively reflect the overall situation of Internet development in our province in 2022, the Provincial Communications Administration and the Provincial Internet Association jointly compiled the 2022 Henan Internet Development Report, which will be officially released today. In order to let everyone know more about the situation, we invited responsible comrades from the Provincial Communications Administration, the Provincial Internet Association and related communications companies to attend, and asked them to focus on the specific contents of the Report and the information and communication work in our province, and to answer questions that the media paid attention to.

  First of all, introduce the publisher who attended today’s press conference:

  Mr. Chang Jiang, member of the party group and deputy director of the Provincial Communications Administration;

  Mr. Zhao Huiqun, Honorary Chairman of Provincial Internet Association;

  Mr. Fan Peiquan, Member of the Party Committee and Deputy General Manager of Henan Mobile Company;

  Mr. Chen Shigang, Member of the Party Committee and Deputy General Manager of Henan Unicom Company;

  Mr. Li Jirui, Senior Vice President of Henan Telecom Company.

  Next, please let Mr. Chang Jiang make a briefing.

often

  Chang Jiang, member of the Party Group and Deputy Director of the Provincial Communications Administration

  Friends of the press:

  Good afternoon everyone! To commemorate the World Telecommunication and Information Society Day in 2023, today, the Provincial Communications Administration and the Information Office of the provincial government jointly held a press conference on the 2022 Henan Internet Development Report.

  According to the agenda of the conference, I will briefly brief you on the 2022 Henan Internet Development Report from two aspects.

  First, the main contents of the 2022 Henan Internet Development Report

  In 2022, under the guidance of Socialism with Chinese characteristics Thought of the Supreme Leader in the New Era, the Internet industry in Henan Province fully implemented the spirit of the important exposition of General Secretary of the Supreme Leader on developing the digital economy, implemented the digital transformation strategy in depth according to the decision-making arrangements of the provincial party committee, the provincial government and the Ministry of Industry and Information Technology, accelerated the construction of new digital infrastructure, and actively built an important information communication hub and information distribution center in the country. Vigorously promote the deep integration of digital technology and the real economy, improve the comprehensive network management system, improve the level of network security, support the development of digital economy, and help build a strong province, a strong network and a digital Henan in all directions.

  In order to comprehensively and objectively reflect the development of the Internet industry in Henan Province, help the digital transformation of the economy and society, and promote high-quality development, the Bureau and the Provincial Internet Association have compiled and published the Henan Internet Development Report for 10 consecutive years. The 2022 Henan Internet Development Report is divided into five chapters and eleven chapters, which systematically summarizes the basic situation and main achievements of the Internet industry development in our province in 2022.

  (1) Basic Internet resources. In 2022, the total bandwidth of Zhengzhou national Internet backbone direct connection point reached 1920 g; The total number of 5G base stations in the province reached 153,200, ranking fifth in the country, with a year-on-year increase of 57.8%; The total number of 10 Gigabit passive optical networks (10G-PON) and above ports reached 850,300, up 97.7% year-on-year. Nine cities, including Zhengzhou, were rated as Gigabit cities by the Ministry of Industry and Information Technology.

  (2) Internet users. In 2022, the number of netizens in our province was 90.832 million, the Internet penetration rate reached 91.6%, and the number of mobile phone netizens was 89.155 million. The total number of Internet users in the province reached 133 million, ranking fourth in the country. Among them, there are 94.09 million mobile Internet users, ranking third in the country; There are 39.348 million Internet broadband access users, ranking fourth in the country.

  (3) Internet enterprise development. In 2022, there were 1,152 new Internet enterprises in our province, up by 14.7% year-on-year, and the total number reached 8,986, ranking third in the country, holding 15,922 licenses for value-added telecommunications services.

  (4) Internet applications. In 2022, 1,470 5G application projects were replicated and promoted in 16 key industries in our province, including equipment manufacturing, coal mine, steel and cement, among which 21 projects won prizes in the national finals of the 5th "Blooming Cup" 5G application competition. Online payment, instant messaging and online shopping are widely used in the personal consumption field of netizens, with user penetration rates reaching 95.4%, 95% and 92.3% respectively. The rate of "one door" of government service matters of "Henan Affairs Office" reached 94%, and the level of integrated government service capacity entered the first place in the country.

  Two, in 2022, the development of Internet in our province mainly presents five remarkable characteristics.

  (1) Internet enterprises have flourished and the capacity of inclusive services has been innovated and improved. In 2022, there were 14 new Internet enterprises above designated size in the province, with a total of 56, and the income from Internet business reached 32.27 billion yuan. Among them, two companies, such as Henan Zhonggang Net and Zhongyuan Dayi, earned more than 10 billion yuan in Internet business, and were selected as one of the top 100 Internet companies in China. Eight Internet companies, including Henan Zhongcheng Information Technology, were selected as "specialized and innovative" small giant enterprises by the Ministry of Industry and Information Technology, and 56 Internet companies, including Zhengzhou Xinda Jiean, were selected as "specialized and innovative" small and medium-sized enterprises in Henan Province. The construction of digital villages was accelerated, and 151 5G+ smart agriculture projects were replicated and promoted. The transaction volume of cross-border e-commerce in our province reached 220.92 billion yuan, up 9.5% year-on-year. The development level of "Online Silk Road" ranked third in the country, providing "Henan Plan" for cross-border e-commerce nationwide.

  (2) The integrated application of "5G+ Industrial Internet" has accelerated the replication and promotion, and the development of industrial Internet has begun to take shape. In 2022, 1,470 5G application projects were replicated and promoted in 16 key industries such as equipment manufacturing, coal mine, steel and cement. The application of 5G industry penetrated into 16 categories and 56 sub-industries, and the province’s 5G application ranked first in the country. The construction of industrial Internet platform system was accelerated, and the construction and application of secondary nodes of industrial Internet logo analysis in Luoyang, Luohe, Xuchang, Xinxiang and Zhengzhou continued to deepen. The application of "5G+ industrial Internet" scene was accelerated, 919 smart factories were built, and 35,800 enterprises were added to the cloud platform, which continued to promote the high-end, intelligent and green development of manufacturing.

  (3) The construction of 5G and Gigabit optical networks was accelerated, and the construction of new digital infrastructure achieved remarkable results. In 2022, our province will promote the coordinated development of 5G and Gigabit optical networks, realize continuous coverage of 5G networks and full coverage of Gigabit optical networks in areas above towns and villages, and the network scale ranks first in the country. The total number of 5G users in the province reached 36.824 million, ranking third in the country. Broadband access users above 1000M accounted for 21.2%, ranking second in the country. Nine cities, including Zhengzhou, Luoyang, Pingdingshan, Xinxiang, Jiaozuo, Xuchang, Nanyang, Xinyang and Jiyuan, were rated as Gigabit cities by the Ministry of Industry and Information Technology, while Luoyang and Nanyang were confirmed as pilot projects of IPv6 technology innovation and integration application by 12 departments including the Central Network Information Office.

  (4) The status of information communication hub and information distribution center has been continuously strengthened, and the base of digital economy has been further consolidated. Zhengzhou Internet backbone direct connection points continued to expand, with a total bandwidth of 1,920 g, up 18.5% year-on-year. The average delay within and between Internet networks ranked first and third respectively in China. The inter-provincial export bandwidth of Internet reached 83.1T, ranking fifth in China, with a year-on-year increase of 36.1%. China Mobile and China Unicom’s 5G regional centers carry core network services in five provinces, with a network capacity of 98.49 million households. There are 37,000 server racks in six super-large data centers deployed in our province by the three major national communication groups, with an export bandwidth of 47T and a computing power scale of 437.3P. Accelerate the construction of ultra-large capacity optical transmission system and continuously improve the carrying capacity of the "three vertical and three horizontal" optical cable trunk network in our province.

  (V) The industry development policy continued to exert its strength and the development environment was further optimized. In 2022, the Regulations on the Promotion of Digital Economy in Henan Province was implemented, and the Regulations on Network Security in Henan Province was issued. The goal of building a comprehensive network management system in three years was achieved as scheduled. The protection capability of key information infrastructure has been continuously improved, and the construction of network security systems in new convergence areas such as 5G, industrial Internet and car networking has been accelerated, further building a network security barrier. Continue to carry out a series of special actions such as "Clear" and "Clean Net", thoroughly implement the "Nine Actions" of network civilization, shape and purify cyberspace with the new trend of the times, and effectively safeguard the security and stability of cyberspace in the province. Successfully held the fifth "Tianan Cup" professional skills competition for network security administrators, and built a network security team with superb technology and excellent quality.

  In the process of compiling the Report, we received strong support from the Information Office of the Provincial Party Committee, the Provincial Development and Reform Commission, the Provincial Department of Finance, the Provincial Department of Industry and Information Technology, the Provincial Department of Agriculture and Rural Affairs, the Provincial Department of Commerce, the Provincial Administrative Examination and Approval and Government Information Administration, the Henan Branch of the National Security Center and other relevant Internet companies in the province. I would like to express my heartfelt thanks.

  My friends, it’s just the right time for Qian Fan to compete for the spring tide. On a new journey, guided by the Supreme Leader’s Socialism with Chinese characteristics Thought in the new era, we will speed up the construction of new digital infrastructure, continuously improve the network supply capacity, deepen the empowerment effect of integrated applications, and make new and greater contributions to the construction of a strong province, a strong network and a digital Henan.

  Thank you!

  Chang Yiyuan, Director of Press Release Office of Propaganda Department of Provincial Party Committee

  Thank you, Director Chang, for your detailed release! Next, welcome reporters and friends to ask questions on issues of concern. Please inform the news organizations you represent before asking questions.

  China news service reporter

  We have learned that the information, communication and Internet industries in Henan are deeply implementing the digital transformation strategy, which has effectively stimulated the vitality of the development of the digital economy. Excuse me, what measures will Henan information, communication and Internet industry focus on in the next step to further consolidate the base of digital economy and promote high-quality economic and social development? thank you

  Chang Jiang, member of the Party Group and Deputy Director of the Provincial Communications Administration

  Thank you for your question. This year is the first year to thoroughly implement the spirit of the 20th Party Congress, an important year to start building a socialist modern country in an all-round way, and a crucial year to carry out the 14th Five-Year Plan. The province’s information, communication and Internet industry will conscientiously implement the spirit of the 20th Party Congress, continue to deepen cooperation with relevant departments of the province in accordance with the work arrangements of the provincial party committee, the provincial government and the Ministry of Industry and Information Technology, accelerate the construction of new infrastructure and modern industrial system, agile and efficient information and communication industry supervision system, comprehensive information and communication service system benefiting the people, stable and reliable network and data security system, and give full play to the strategic, basic and priority of services to support economic and social development in promoting the deep integration of digital economy and real economy.

  First, we must resolutely do a good job as a builder of new infrastructure. Adhere to a blueprint to the end, pay close attention to the implementation of the "14 th Five-Year Plan" series, and promote the task project, project list and list responsibility. Create a 5G boutique network. In 2023, 34,000 new 5G base stations will be built, and the total number of 5G base stations in the province will exceed 180,000 by the end of the year. The coverage rate of key scenes, hot spots and rural hot spots will reach 100%, and the coverage rate of administrative villages in the province will exceed 90%. Building a Gigabit Network Demonstration Province. We will carry out the "light-chasing action" for Gigabit optical networks, adding 300,000 ports of 10G-PON and above, with a total number of more than 1.1 million ports, realizing the comprehensive deployment of 10G-PON equipment above towns and villages, and striving to add more than five "Gigabit cities". Continue to build Zhengzhou into an important communication hub in China. Improve the direct connection function of Zhengzhou’s national Internet backbone, promote the optimization of network structure and high-speed direct connection, and build a four-level computing time delay circle of 1 millisecond for local cities, 3 milliseconds for Zhengzhou-Luoyang metropolitan area, 5 milliseconds for provincial areas and 20 milliseconds for the whole country. Promote the construction of information distribution centers and central computing network hubs. Create a data resource pool of national hotspot areas, accelerate the construction of five super-large green data centers of the three major national communication groups, add 20,000 racks, with the total number exceeding 50,000, and build a central computing center with deep integration of cloud networks to provide enterprises and individual users with a higher quality and high-speed computing application experience.

  Second, we must resolutely do a good job in the practitioners of the "5G+ Industrial Internet" integrated application. Adhere to the complete, accurate and comprehensive implementation of the new development concept, make good use of the golden key of integration and application, continue to release the industry empowerment effect, and strive to promote high-quality development. Continue to promote large-scale replication and promotion in key areas of 5 G. Adhere to the "wholesale" thinking, accelerate the large-scale application of 5G technology around key industries such as industry, medical care, agriculture, transportation, cultural tourism and education, three key areas such as steel, coal mine and cement, and seven trillion industrial clusters such as equipment manufacturing, green food, new materials, electronic information, energy conservation and environmental protection, modern textiles and green building materials. The total number of 5G application projects in key industries in which the information and communication industry in the province participates in construction and operation exceeds 2000. Continue to promote the development of high-end, intelligent and green manufacturing. In-depth development of industrial internet integration into the park "100 cities and thousands of parks" activities, and promote the development of 5G large-scale application and identification analysis system application in industrial parks. Promote the popularization and promotion of industrial Internet logo analysis secondary node applications in various cities, and expand the industrial Internet industry ecosystem. Continue to promote the construction of digital villages. We will implement five major projects, including rural 5G and 4G network coverage, and solidly promote the rural 5G "lighting" work. Combined with the construction of 15 million mu of high-standard farmland demonstration area in the province, in accordance with the requirements of equipment modernization, intelligent application, standardized management and ecological environment, we will accelerate the replication and promotion of high-standard farmland 5G+ smart agriculture projects in the province.

  Third, we must resolutely do a good job in maintaining network and data security. Adhere to the overall national security concept and build a strong network security barrier to provide strong support for the construction of a strong province, a strong network province and a digital Henan. Continue to consolidate the security cornerstone of key information infrastructure in the industry. Comprehensively improve the ability of basic telecommunications networks to cope with major risks, and complete network security tasks in important periods with high quality. Innovate and improve the security guarantee ability in the new integration field. We will continue to strengthen the construction of a demonstration center for 5G application security innovation, enhance the supply capacity of 5G application products, and promote the development of the province’s 5G security industry. Carry out special actions on industrial Internet security to protect the network security of industrial Internet. Solidly promote industry data security management. Carry out the special action of data security risk management of "Digital Security Escort" in the industry, which strongly supports the implementation of digital transformation strategy in our province.

  Fourth, we must resolutely be a good service provider of digital benefits to the people. Adhere to the people as the center, improve the level of information and communication services for people’s livelihood, meet the people’s growing needs for a better digital life, and let the people have more sense of gain, happiness and security in the development of informationization. Strengthen the construction of morals and rectification. Guide enterprises to highlight service orientation and further promote service upgrading. Upgrade iterative network to apply aging-adaptive features to further enhance the convenience and accessibility of aging-adaptive services. Regularly rectify junk information, deepen the prevention and control of telecommunication network fraud, and earnestly safeguard the property safety and legitimate rights and interests of the people. Improve the digital service capability. Increase the publicity and implementation of the Regulations on Telecommunications in Henan Province. Optimize telecom market access and promote the pilot of electronic licenses. Improve the level of integration supervision in internet plus, strengthen the standardization of the Internet market order, and actively cooperate with relevant departments to carry out special actions such as network clearing.

  Under the correct leadership of the provincial party committee and the provincial government and the Ministry of Industry and Information Technology, the information, communication and Internet industries in the province will forge ahead bravely, strive to write a more brilliant chapter of Henan’s information and communication industry in the new era, and make new and greater contributions to solidly promoting the practice of Chinese modernization in Henan!

  thank you

  Reporter from the Central Radio and Television General Station Yang Guangwang

  In 2022, the Internet industry in Henan Province maintained a good development momentum, especially in the scale and income of Internet companies. Excuse me, what are Henan’s plans to become a stronger and better Internet enterprise and promote the prosperity and development of the Internet industry this year? thank you

a surname

  Zhao Huiqun, Honorary Chairman of Provincial Internet Association

  Thank you for your concern about the Internet industry in our province. In 2022, under the correct leadership of the Provincial Party Committee, the provincial government, the Ministry of Industry and Information Technology, under the specific guidance of the Provincial Communications Administration, and with the strong support of the provincial Party Committee Network Office, the Provincial Development and Reform Commission, the Ministry of Industry and Information Technology and other relevant departments, the Provincial Internet Association implemented the digital transformation strategy in depth, focused on key tasks such as "promoting the application of 5G scale" and "making Internet enterprises stronger and better", played a role as a bridge and industrial Internet platform, and continuously improved its service capabilities, and achieved industrial development.

  This year, the Provincial Internet Association will conscientiously implement the spirit of the 20th Party Congress, with the aim of "serving members’ needs, industry development, government governance and digital economy", and continue to optimize four brand activities, such as Henan Internet Conference, Henan Internet Development Symposium, Henan Internet Development Report and comprehensive strength research of Internet enterprises, and actively promote the Internet enterprises in our province to become stronger, better and bigger, and promote the high-quality development of the Internet industry in our province.

  First, vigorously cultivate leading enterprises and promote the development of industrial clusters. Actively organize and participate in China Internet Conference, China International Big Data Industry Expo and other major domestic Internet activities, strengthen exchanges and docking with leading enterprises and unicorn enterprises outside the province, and actively strive for relevant platform projects of leading enterprises to land in Henan. Every year, we select a group of innovative enterprises with development potential in the province, increase cultivation efforts, and build leading enterprises and innovation benchmark enterprises in our province. Organize research on the comprehensive strength of Internet enterprises, discover, cultivate and build a number of Internet enterprises with potential and good growth, and build local high-quality brands. We will continue to carry out the series of activities of "ten thousand people help ten thousand enterprises" and continue to implement the "grading service standard for member units of Henan Internet Association" to help Internet enterprises solve practical difficulties and enhance their innovation vitality. Relying on the carrier of industrial parks such as Zhongyuan Science and Technology City, leading enterprises, unicorn enterprises and "specialized and innovative" enterprises are encouraged to actively participate in the carrier construction, and promote the formation of a core gathering area with diversified investment, professional service, distinctive features and relatively concentrated space.

  The second is to continue to promote the large-scale application of 5G and serve the development of the digital economy. Assist in the preparations for the Henan Regional Competition of the "Blooming Cup" 5G Application Collection Competition, and select typical cases of 5G applications. In-depth interpretation of outstanding award-winning application projects of 5G, exhibition tour of outstanding cases, full display of the latest achievements of 5G applications, creation of demonstration benchmarks of 5G applications, and digital transformation and development of industries with 5G demonstration applications. Continue to carry out 5G application and digital transformation exploration activities, carry out 5G application exchanges and research in different industries, organize experts to "check the pulse", understand the replication and promotion of 5G applications in various fields on the spot, and further promote the deep integration of digital economy and real economy.

  The third is to create an Internet development ecology and promote the high-quality development of the industry. We will continue to run the Songyang Digital Economy Lecture Hall, Songyang Qiangwang Salon and other activities, build a supply-demand exchange platform between local traditional enterprises and digital service-oriented enterprises, promote the transformation of innovation achievements and promote industrial innovation and development. Hold special activities such as Henan Internet Industry Vocational Skills Competition, assist in the technical training of "industrial Internet logo analysis system" and the qualification certification training of "industrial Internet practitioners" and "Internet industry practitioners" to improve the quality of the talent team in the Internet industry. Encourage enterprises and universities to jointly set up college students’ entrepreneurial bases, establish an industrial talent recruitment and training supply service system, and provide high-quality digital talent support for industry development.

  The Provincial Internet Association will conscientiously implement the work deployment of the Provincial Communications Administration, take the "four services" as the starting point, continue to unite all its members, be honest and innovative, be realistic and pragmatic, play the role of a bridge and an industrial Internet platform, help Internet enterprises in our province become stronger and better, promote the prosperity and development of the Internet industry, and make new and greater contributions to the construction of a strong network province and digital Henan. thank you

  Henan Daily reporter

  In 2023, the government work report of the two provincial conferences proposed to speed up the construction of a strong manufacturing province and focus on building an advanced manufacturing system. Excuse me, what achievements has Henan Mobile made in promoting the digital transformation of manufacturing industry in our province relying on the provincial comprehensive industrial Internet platform? In order to further play the role of industrial Internet platform, what will Henan Mobile focus on in the next step? thank you

model

  Fan Peiquan, Member of the Party Committee and Deputy General Manager of Henan Mobile Company

  Thank you for your question. Henan is a big economic province and a big emerging industrial province. According to the work arrangements of the provincial party committee, the provincial government and the Ministry of Industry and Information Technology, Henan Mobile has fully played the role of digital leading, inciting and empowering, and vigorously promoted "Made in Henan" to "Made in Henan" by building an industrial Internet platform and building a 5G benchmarking demonstration project, which effectively promoted the optimization and upgrading of the industrial structure in our province. At present, the platform has supported more than 840 industrial Internet projects in the province, and landed more than 700 5G fully connected factory projects in the province, which effectively promoted the industrial Internet platform to be embedded in the whole process of enterprise production and operation, and promoted the digital transformation of manufacturing industry in our province.

  The first is to create a demonstration benchmark to promote the optimization of industrial structure. At present, Henan Mobile Industrial Internet Platform is equipped with 60 industrial apps and 79 mechanism models covering new materials, equipment manufacturing, mining, metallurgy and other industries, providing a one-stop solution for industrial enterprises to "use numbers to enrich their wisdom". Henan Mobile cooperated with China Railway Equipment to build the "5G+ Smart Shield" project, Zhengzhou Baoye Steel Structure to build the first domestic 5G steel structure factory, citic heavy industries to build the "5G+ Smart Factory" project and Jiaozuo Chiba Cement to build the "5G Green Unmanned Mine" project. In particular, the project of "5G+ Smart Factory" tailored in conjunction with Zhengzhou ruitai has instigated the transformation and upgrading of the refractory industry in our province through its benchmarking demonstration.

  The second is to build an ecological circle and build a strong industrial chain. Henan Mobile continued to build an ecological chain of digital industry, and built a digital innovation chain of "one hospital, one room, one center and one alliance" in our province. It successively landed in China Mobile’s "Lianchuang+"Henan 5G Open Laboratory and China Mobile (Zhengzhou) Industrial Internet Research Institute and Digital Rural Research Institute, and established the Henan 5G+ Industrial Internet Ecological Alliance; It has introduced more than 120 partners from all over the country, set up 11 joint innovation lab, such as "5G+Smart Factory", and built five training bases, such as "5G+Machine Vision", thus building an open and innovative ecology with win-win cooperation.

  The third is to actively go out and create a new business card in Henan. Since 2020, in the "Blooming Cup" National 5G Application Competition held by the Ministry of Industry and Information Technology, Henan Mobile has achieved good results for three consecutive years, fully demonstrating the wisdom and strength of Henan in the digital economy. In the final of the 5th National 5G Application Collection Competition Smart Energy Thematic Competition, which ended in Zhengzhou last September, Henan Mobile won five first prizes for the demonstration projects created by Pingmei Shenma Group, Foxconn Zhengzhou Factory, Xinxiang Chemical Fiber and other leading enterprises. In the future, Henan Mobile will export these benchmark projects to the whole industry, becoming an important starting point for the digital transformation of traditional industries and a new business card for Henan’s digital economy.

  The fourth is to promote the upgrading of the platform and continuously enhance the empowerment. Henan Mobile has continuously promoted the upgrading of provincial-level comprehensive industrial Internet platforms. At present, it has built regional industrial Internet platforms in Luoyang, Kaifeng, Zhumadian, Xinyang, Zhoukou and other cities, built industrial Internet platforms in steel structures, refractories and other industries, and built industrial Internet platforms in Jiaozuo Haohua Aerospace and Qinyang Chemical, further building them into comprehensive industrial Internet platforms across industries and fields.

  This year, Henan Mobile will continue to promote the construction of new information infrastructure focusing on the 5G+ industrial Internet platform, and innovatively build a new information service system of "connection+computing power+capability". We will vigorously implement the "four projects".

  The first is to implement the network strong foundation project. This year, Henan Mobile plans to invest more than 10 billion yuan to build 21,000 new 5G base stations, improve new infrastructure such as 5G, optical fiber network, data center and computing network, help enterprises in our province to implement internal and external network transformation, and effectively promote Henan to become an important information communication hub and information distribution center in China.

  The second is to implement the platform empowerment project. Henan Mobile will continue to increase investment in technology and resources for the platform, and deploy 50 industrial apps and 60 mechanism models online this year, and radiate 1,000 industrial enterprises within two years; Promote the iteration of upgrading the comprehensive industrial Internet platform, accelerate the nine platforms of China Mobile Group, such as smart city platform, smart park platform and high-precision positioning platform, and empower industrial Internet platforms in various regions, industries and parks to blossom in the province.

  The third is to implement the ecological expansion project. Henan Mobile will continue to build a strong "one hospital, one room, one center and one alliance" intelligent innovation chain, promote China Mobile to cooperate with R&D institutions such as Henan Academy of Sciences, Songshan Laboratory and Longmen Laboratory, and universities such as Zhengzhou University and Henan University, continue to expand the circle of ecological partners, gather excellent ecological capabilities of major industries in China, build a high-end digital technology innovation platform, help our province build a strong industrial chain, and boost the digital transformation and development of our province.

  The fourth is to implement the industry bloom project. Henan Mobile will continue to build a 5G benchmarking project and actively empower thousands of industries to ensure that it will continue to maintain its leading position in major competitions such as the 2023 National 5G Blooming Cup.

  Henan Mobile will further implement the digital transformation strategy, give full play to the advantages of the industrial chain, accelerate the digital transformation of thousands of industries, and contribute more mobile wisdom and power to the all-round construction of digital Henan and the Central Plains! thank you

  Henan radio and TV reporter

  This year’s government work report proposes to build a gigabit network demonstration province. In 2022, nine gigacities have been built in Henan Province. Excuse me, what achievements has Henan Unicom made in promoting the construction of gigabit cities and deepening the application of gigabit optical networks? What are the next steps? thank you

the Chen Dynasty

  Chen Shigang, Member of the Party Committee and Deputy General Manager of Henan Unicom Company

  Thank you for your question and concern about our work. The "Double Gigabit" network represented by Gigabit optical network and 5G is an important component and bearing base of new infrastructure, which plays an important role in stimulating effective investment, promoting new consumption and empowering digital transformation of industries. In 2022, Henan Unicom actively implemented the major strategic requirements of the CPC Central Committee and the State Council on network power, digital China and digital economy, and implemented the "Double Gigabit Network Collaborative Development Action Plan (2021-2023)" of the Ministry of Industry and Information Technology, and vigorously promoted the construction and application innovation of "Double Gigabit" networks in accordance with the relevant work arrangements of the provincial party committee and the provincial government, so as to help high-quality economic and social development.

  First, promote the construction of Gigabit networks and lay a solid foundation for development. In terms of 5G network construction, deepen co-construction and sharing and industrial cooperation, build a 5G boutique network with comparable coverage, leading experience, leading ability and leading efficiency, and build a total of 70,000 5G base stations to enhance breadth and depth coverage; In terms of Gigabit optical network construction, we will promote the upgrading of key areas. The proportion of 10G PON in the province has reached 33.3%, and more than 5,000 all-Gigabit demonstration communities have been built, achieving full coverage of 10G PON in towns and villages and key rural areas in the province, and applying OLT’s big data analysis capabilities on a large scale to enhance user perception. The broadband experience download rate of the Ministry of Industry and Information Technology ranks first in the industry.

  The second is to speed up gigabit capacity building and inject new kinetic energy into development. Unicom (Henan) Industrial Internet Co., Ltd. was established to build a professional platform based on its own resource endowments, build an independent product system in many fields, and provide comprehensive services integrating marketing support, solutions, product research and development, integrated delivery and operational service resources. Relying on the advantages of double Gigabit, we pioneered the research and development of public service platforms for smart cities in counties, and incorporated cutting-edge technologies such as 5G, AI and big data to realize the integration of urban spatial governance and urban operation, creating a number of benchmark projects such as Smart Central Plains, Jiaozuo Liberated Area and Pingdingshan jia county. We have developed a digital village platform, built a digital village pedestal, empowered rural development and rural services, and promoted the modernization of rural governance capacity. More than 1,000 scenes including Xixia County in Nanyang, Houhe Town in Changge, Xuchang and Nianzigou Village in Sanmenxia have been deployed and applied.

  The third is to deepen gigabit application innovation and create a new model for development. In the government industry, gather multi-source data such as coal, electricity, oil and gas transportation, government affairs, mobile phone signaling, establish a big data analysis model, and build the first "economic operation monitoring and analysis platform" of the provincial development and reform commission in China to provide effective support for macroeconomic decision-making; In the field of industrial internet, build a "Henan Province 5G Industrial Internet Enterprise Cloud Platform" to provide basic capabilities for the digital transformation of enterprises; In the steel industry, United Angang Group unveiled the 5G Smart Steel joint innovation lab, and carried out in-depth cooperation in 5G applications with enterprises such as Angang, Jigang and Xinyang Iron and Steel; In the agricultural industry, we jointly built the "5G+ Smart Orchard in Guanmiao Village, Madian Town, Luoning County" with the government of Luoning County, combined with 5G and VR technologies to promote the transformation of traditional orchards into sightseeing and leisure orchards, and won the first prize in the fifth "Blooming Cup" national finals.

  In 2023, Henan Unicom will focus on three aspects around supporting the construction of a gigabit network demonstration province.

  First, focus on the improvement of network capabilities and promote the coordination of Gigabit "end network industry". Based on customer needs, strengthen network industry collaboration and provincial and municipal linkage, and build 12,000 new 5G base stations; Accelerate the construction of the center of the central region of the 5G core network, enhance the service carrying capacity, and consolidate the status of the 5G network hub in our province. The proportion of 10G PON ports is over 45%. Actively promote the remaining nine cities to pass the evaluation and certification of gigabit city construction.

  The second is to focus on improving customer experience and accelerate the popularization of Gigabit networks. In terms of network speed, based on the double gigabit network, the new Unicom broadband standard is redefined to realize "all-fttp, all-house optical broadband, and all-family real gigabit" to ensure the home users’ extremely fast surfing experience. In terms of services, customized services are launched to meet the needs of home users, making wiring more beautiful and creating a new broadband service model of "broadband+application+network service". In terms of smart life, more than 200 kinds of smart devices are adapted, and services such as China Unicom housekeeping and China Unicom Ultra HD are launched to create smart products for the whole house.

  The third is to focus on key areas and accelerate the replication and promotion of innovative applications. Promote the replication, promotion and application of Gigabit network applications in the whole industry and all fields. In the field of digital government, taking the construction of an integrated online service platform of e-government network as the starting point, it provides a one-stop service of cloud network with high security, large bandwidth and self-opening; In the field of digital finance, speed up the transformation of boutique network, help customers streamline the computer room of secondary branches, and meet the needs of video banking and network flattening; In the field of smart medical care, provide one-stop service, realize the whole business of the hospital, and empower key application scenarios such as pre-hospital emergency treatment, remote treatment, remote diagnosis, remote intensive care and health management; In the enterprise field, deepen the expansion of 5G technology from peripheral auxiliary links to core control links, and based on the steel industry and relying on 5G smart steel joint innovation lab, complete the application of 5G in more than 90% steel enterprises in the province. In 2023, it is estimated that more than 700 5G application projects will be built, and the cumulative economic benefits will increase by over 2.6 billion yuan.

  Looking forward to the future, Henan Unicom will build a digital base and a digital engine with double gigabit construction, promote the integration and development of digital economy and real economy, empower thousands of industries and benefit thousands of households, and contribute to the construction of digital Henan. thank you

  Top journalist

  As the cornerstone of digital development, cloud computing has become the driving force for the digital transformation of enterprises and governments. Excuse me, what is the effect of Henan Telecom in implementing the strategy of "changing from cloud to digital" to help enterprises get on the cloud and empower social economy and people’s livelihood? What measures will be taken next? thank you

plum

  Li Jirui, Senior Vice President of Henan Telecom Company

  Thank you for your question. In 2022, China Telecom Henan Branch actively implemented the requirements put forward by the 20th National Congress of the Communist Party of China to speed up the construction of a manufacturing power, a network power and a digital China, and made great efforts to practice the development idea of "people-centered". Focusing on the strategy of China Telecom Group to change from cloud to digital, it helped to build a strong digital province in an all-round way, laid out emerging digital industries such as cloud services and computing power, and focused on digitalization, intelligence, integration and convenience to help build a modern Henan with high quality.

  First, speed up the construction of digital infrastructure and help build a new highland of national computing power. China Telecom Henan Branch adheres to the guidance of "Cloud Network Convergence 3.0", seizes the strategic opportunity of "East Counting and West Counting", gives full play to the location advantage of the central part of Henan, which is "the hinterland of Kyushu and the thoroughfare of ten provinces", continuously expands the scale of the national cloud computing infrastructure, realizes the deployment of nearly 70,000 TFLOPS computing power, and initially forms a hierarchical computing power system with echelon distribution and cloud edge coordination. The central data center realizes the delivery of nearly 1,000 racks of the 1# machine building, creates the speed of Henan, and strongly supports the layout of national cloud, IDC and security resource pools and the construction of core and backbone nodes of Internet head customers; To lay a solid foundation for the comprehensive information service ability of customers and individual customers in the government, finance and other industries in our province.

  The second is to build a national cloud, fully empower thousands of industries and accelerate the development of the digital economy. China Telecom Henan Branch has continuously promoted the evolution and upgrading of the basic cloud base through new technologies such as multi-core in one cloud, multi-state in one cloud and multi-calculation in one cloud. Actively participate in the construction of key platforms such as provincial and municipal government cloud, Xinchuangyun, Disaster Recovery Cloud and State-owned Cloud; In the field of Xinchuang, we will combine our own advantages of Xinchuang Cloud and Xinchuang Cloud Computer, and help build the province’s Xinchuang Ecological Circle around the national Xinchuang product adaptation base, forming a number of government application benchmark projects such as provincial and municipal government cloud, county-level Xinchuang Cloud and Xinchuang Cloud Computer. Up to now, China Telecom Henan Branch has built 19 self-developed cloud bases in the field of government affairs and state-owned assets in the province, and 18 cities have built one city and one pool, which provides a solid foundation and guarantee for the application of government affairs at all levels in provinces, cities and counties, all kinds of state-owned enterprises and innovation applications.

  China Telecom Henan Branch has served more than 10,000 customers in helping enterprises to go to the cloud, focusing on the key production links of enterprises, relying on Tianyi Cloud, AI application, big data analysis and cloud management capabilities for empowerment transformation, and has provided services in nearly 10 sub-sectors such as food, medicine, printing, textile, equipment manufacturing, electronic manufacturing, steel, coal mine and cement. Through the deep integration of Tianyiyun +5G, the digital innovation of key industries will be realized, and the Internet platform of Oriental Hongyun Agricultural Machinery and Equipment Industry will be jointly built with China Yituo to provide real-time agricultural machinery operation monitoring services for over 50,000 agricultural machinery and equipment; Cooperate with Detong Vibration to build an industrial Internet platform for the mixing industry, provide online monitoring and mixing station management services for over 10,000 mixers, and effectively improve the efficiency of enterprise operation and management; Build an industry cloud with SAIC, and integrate cloud computing with SaaS and PaaS capabilities of SAIC’s industry characteristics, such as smart driving cloud, smart cloud and trusted cloud, to provide cloud network services and safe operation services for more than 200 eco-chain enterprises in SAIC, enabling the added value of industrial output value to exceed 200 billion yuan.

  In 2023, China Telecom Henan Branch will continue to implement the decision-making arrangements of the provincial party committee and government on promoting the deep integration of the digital economy and the real economy, and do a good job in the following work:

  First, continue to accelerate the construction of digital infrastructure. The province plans to add 120,000 TFLOPS of computing power, carry out diversified deployment, promote diversified supply of computing power, and realize the coordinated development of general computing power, super-intelligent computing power and high-performance computing power in the province, laying a solid foundation for building a computing highland in central China and undertaking the demand for low-delay spillover computing power in eastern China. Accelerate the construction of China Telecom’s central data center, build a leading super-large green data center in China, plan to add more than 3,000 racks, and strive to build the central data center into the fifth hot regional resource pool of China Telecom’s intelligent computing service system in Henan.

  The second is to consolidate the development base of the digital economy and help empower economic and social transformation and upgrading. In-depth implementation of the "cloud to digital" strategy, adhere to the "cloud as the core, cloud network integration", give full play to the advantages of full-stack self-research technology and a full range of products as cloud service providers, innovate and build a digital service capacity base, closely fit in with the construction of digital government in Henan Province, accelerate the innovation and transformation of information systems of governments at all levels, state-owned enterprises and key industry units, and create autonomous, controllable, safe, credible, intelligent and agile cloud and application scenarios, thus making due contributions to the innovation work in our province. At the same time, we will accelerate the digitalization of smart education, medical health, cultural services and other fields, take Tianyi Cloud as the cloud base, accelerate the promotion of cloud in the industry, and promote the transformation and upgrading of enterprises.

  Today is the "World Telecommunication and Information Society Day", and China Telecom is also the first in the industry to release a computing package today, promoting computing power to empower thousands of industries and helping the development of the digital economy. In the next step, China Telecom Henan Branch will continue to explore and innovate, give full play to the advantages of emerging technologies such as cloud, AI and video networking, speed up infrastructure construction, strengthen services to the people’s livelihood, continuously promote the development of digital economy in our province, and actively contribute to the construction of a strong manufacturing province, a strong network province and a digital Henan!

  Thank you!

  Chang Yiyuan, Director of Press Release Office of Propaganda Department of Provincial Party Committee

  Thank you for your answers. That’s all for today’s on-site questioning session. If journalists and friends have other questions that need further understanding, they can contact the relevant publishing units for an in-depth interview after the press conference. Here, I hope that all news media can, as always, pay attention to supporting the development of information, communication and Internet industry in Henan, deeply publicize the key measures and highlights of our province’s overall promotion of network security and informatization development, vigorously publicize and popularize network security knowledge, promote the whole society to form a good atmosphere in which network information is shared by everyone and network security is everyone’s responsibility, and help build a strong province, a strong network and a digital Henan in all directions, so that the achievements of Internet development can better serve the overall situation of economic and social development and better benefit people’s production and life.

  This concludes today’s press conference. Thank you, publishers, journalists and friends. Goodbye.

Online drama "blockbuster" competition, thick text wins.

  Suspense short plays, represented by Extraordinary Witness, White Moonlight and Skyscraper, have been regarded as the most competitive type in the domestic online drama market. (All TV series posters) Cartography: Li Jie

  The popularity of online dramas has been rising for several months. The three major video websites of "Ai Youteng" have previously launched three suspense short plays, Very Witness, White Moonlight and Skyscraper, which have all divided the attention of young drama fans. These three suspense short plays have been regarded as the most competitive types in the domestic online drama market-movie stars with excellent acting skills, film directors with strong image style, and details of service that can stand the "close shot" of personality, all of which give these works an audio-visual quality beyond ordinary TV dramas.

  Interestingly, these three productions have their own advantages, and the lineup behind the scenes is equal. At present, the Douban scores obtained show an obvious ladder arrangement: Skyscraper 8.1, White Moonlight 6.6 and Extraordinary Witness 5.6. Judging from the comments of fans, it is the script itself that determines the score. What echoes this is the fact that among the three works, only Skyscraper, which has the highest score, is an adaptation based on a literary background, while the previous Hidden Corner is also adapted from a successful genre novel.

  It is true that excellent novels can not be equated with excellent film and television dramas, but the performance of recent hot dramas has forced people to see that high-quality literature books are the "escort" of the series. In the eyes of people in the industry, online dramas entering the era of high-quality blockbusters are paying more and more attention to literary works with humanistic thickness and literary value. On the contrary, it is easy to become a mystery in the eyes of the audience without the support of rich and thick texts and the addition of literary forms.

  Typed creation with a large lineup has become a powerful starting point for differentiated competition of online dramas.

  The irreplaceable category feature is one of the signs that a literary style is really maturing. Domestic online dramas can compete with traditional categories such as movies and TV dramas, which is due to the innovative methods accumulated by years of differentiated competitive thinking. Among them, the front-stage and behind-the-scenes lineup, typed creation and short film theatrical operation of comparable movies have become the most favorable mode for online dramas to incite the market. The masterpiece of this creative mode is undoubtedly the well-received and well-received Hidden Corner. The intensive publication of three works, Skyscraper, White Moonlight and Extraordinary Witness, has further opened up the operation path of high-quality short plays.

  Skyscraper, which connects the life of a female victim with a murder case, has been praised by the industry as the leader of domestic "her suspense". Just looking at the production lineup, the audience will think that this is a film work: the actors gather "familiar faces" in big screens such as Guo Tao, Yang Zishan, Angelababy, Jiao Gang, Ni Hongjie, Lv Yulai, etc. What surprises the audience even more is that Wang Shengdi, who plays the girl "Pupu" in "Hidden Corner", also plays an important role in the play; Director Chen Zhengdao has directed films such as Master of Memory and Master of Hypnosis that combine business typology with personal style skillfully. Like the first two films directed by the director, Skyscraper also focuses on multi-point narration and plot reversal, so this online drama is also listed as the "Chen Zhengdao Trilogy" together with the first two films.

  White Moonlight, also from the female perspective, tells a suspenseful cheating story. The lineup of this work also aroused great expectations of the audience. Song Jia Jr. partnered with "Lv Xiucai" and Yu Entai’s husband-and-wife combination of "the woman is the master outside and the man is the master inside", which made the audience shine, and more powerful factions such as Liu Mintao and Huang Jue joined in. Liu Ziwei, the director of this drama, was nominated as the "Best Director" in the 19th Shanghai International Film Festival for his debut novel "My Heart is Jumping", and it was the "deep diver" in the field of online drama who escorted the newcomers to the academy-500 who directed hot dramas such as Psychological Crime and Antique close encounter of mahjong as the producer of this film.

  The online drama "Very Witness" and the previous online "Ten Days Game" and "Hidden Corner" belong to the "Misty Theater", which tells a story of chasing the murderer that spans 20 years. Song Yang and Yuan Wenkang, the leading actors in the play, are not big hit stars, but all of them are low-key acting schools with film works. The former has appeared in many domestic films, including The Arrow and the White Ape, Master, The Great Cause of Building the Army and The Chang An Thief. In recent years, a film "Violent Silence" has made Song Yang the best actor in Tokyo Film Festival.

  Professional visitors enter the market, and it is the thickness of the text that is used to compete with the online drama of overseas hot dramas.

  The lineups of the three online dramas are also expected, but the word-of-mouth gained after the launch is quite different: Skyscraper ranks first, White Moonlight ranks second, and Very Witness scores the lowest. Professional audiences who have mastered the right to speak online are divided into three levels, which makes the three "competing products" show a possibility to detect the aesthetic consensus of the current audience. What separates the three works is precisely "the foundation of a drama", and "explosion" relies more and more on the literary and humanistic values in the script.

  Among them, the most humanistic information is Skyscraper supported by a literary copy of the same name. The drama series runs through a female murder case in a skyscraper, but it reflects all the social beings represented by the owners in the skyscraper. In the unfolding of the stories of the suspects, the embarrassing life experiences of the female victims are constantly supplemented. Therefore, the proposition of "Who killed women" has been endowed with double connotations of law and sociology. In the form of expression, the multi-perspective advancement makes the "unreliability" of narrative give more room for suspense and reversal.

  In contrast, White Moonlight, which belongs to the female theme, appears to be more literary than informative. The whole play revolves around a husband’s affair, and the wife who trusts her husband is in doubt and temptation, and finally falls into collapse. This delicate exploration of women’s inner world is worth encouraging, but the conflict between the slow pace and the absent character drama will inevitably lead to a psychological gap among genre lovers. At present, Extraordinary Witness, with the lowest score, has broken the narrative rhythm and weakened the logic of investigation because of the accumulation of redundant stories that are constantly separated from the main line. Every character in the play has mastered part of the truth of the murder case 20 years ago, and this "jigsaw puzzle" narrative opening is amazing. However, the story is already halfway through, and the scattered information still fails to produce a staged confluence. The people in the play pretend to be deep in literary and artistic remarks and beautiful lighting, which makes the series look more like an MV with good sentences but no good chapters.

  Grading with clear steps reflects the young audience’s aesthetic consensus on genre works, and also shows the professionalism and expression desire of contemporary audiences. A noteworthy phenomenon is that in the online reviews of the three works, the names of overseas high-scoring suspense masterpieces such as Dr. Foster, Big and Small Lies and Your Turn appeared. It can be seen that in the audience’s mind, the competitors of high-quality domestic online dramas are no longer domestic TV dramas, but overseas dramas that have gained international recognition. In the face of a well-informed professional audience, the final competition of online drama is the thickness of the text. Reporter Zhang Yuxi